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Ondansetron (Zofran) is a medication used to treat nausea and vomiting. It is especially helpful in nausea and vomiting caused by medications. It has the benefit of fast onset and can sometimes help your pet within 15 minutes. It is generally well tolerated but its use should be cautioned in pets with liver disease and in collies. It can be used in dogs or cats and should be given before meals or medications so it can work properly. Contact your pet's veterinarian or VetRxDirect pharmacist about possible drug interactions with Ondansetron.