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Trifexis is a triple acting parasite prevention treatment for dogs. Trifexis is a prescription heartworm disease preventative that contains spinosad, an insecticide and milbemycin oxime, a parasiticide. It starts killing fleas within 30 minutes, prevents re-infestation, and prevents the tapeworms they carry. Trifexis also treats and controls the infection of 3 intestinal parasites: roundworms, whipworms, and hookworms. It provides 1 month of protection and is a flavored chewable tablet, making it easier to give Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Available in six sizes based on weight: 5-10 lbs, 10.1-20 lbs, 20.1-40 lbs, 40.1-60 lbs, 60.1-120 lbs.