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Leflunomide Rx

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Leflunomide (Generic) Tablets for Cats and Dogs

Leflunomide is a medication that acts as an immunomodulator, or a substance that will affect how the immune system functions. Leflunomide works by inhibiting the production of T-cells and B-cells which are a part of the immune response. Sometimes, overproduction can occur without the need for the production of these cells. Overproduction can lead to inflammation and destruction of healthy tissues.

What you should know about Leflunomide:

Leflunomide is used to treat a variety of conditions such as immune mediated hemolytic anemia (IMHA) or histiocytosis. It has also been used in combination with methotrexate to treat rheumatoid arthritis in cats. It should not be given to pregnant animals or animals with severe kidney failure. Although generally well tolerated, there may be some side effects associated with leflunomide.


  • Side Effects of Leflunomide: decreased appetite, tiredness, vomiting. If you are ever unsure about side effects or how to give this medication to your pet, contact your pet's veterinarian directly.
  • It is important to give leflunomide as your pet's veterinarian has prescribed. If you miss giving a dose, give it to your pet as soon as you remember. If it is close to the next dose, skip the missed dose and continue on your normal schedule. 
  • Wear gloves when handling this medication.
Leflunomide is sold as an FDA approved generic drug. Brand varies from order to order and variation to variation. VetRxDirect is unable to guarantee which brand will be available at the time of order shipment.