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Amitriptyline is a prescription anti-depressant drug called a tricyclic, that affects certain chemicals in the brain that are unbalanced. It it used to control behavior problems in dogs and cats such as anxiety, separation anxiety, excessive grooming, and urine spraying in cats. It is also used in the treatment of chronic nerve pain and severe itching. If your pet has been diagnosed with a behavior disorder your veterinarian may prescribe an antidepressant medication like Amitriptyline. The Amitriptyline transdermal gel is applied topically to a hairless portion of the skin, typically the inner side of the ear lobe, where it absorbs through the skin into the bloodstream. This method is suggested for pets who are difficult to administer oral medication. It is compounded in 2mg, 2.5mg, 3.5mg, 5mg, 7.5mg, 10mg, and 12.5mg strengths. Consult with your pet’s veterinarian before administering this medication.