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Zonisamide Rx

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Zonisamide

Managing epilepsy in dogs can be challenging. To reduce seizures, many veterinarians prescribe Zonisamide. This anticonvulsant medication is effective alone and can be used in conjunction with other anticonvulsants to control the symptoms of refractory epilepsy.

  • Helps reduce seizures in epileptic dogs
  • Effective when used alone
  • Can be combined with other anticonvulsant medications

Controlling epilepsy in dogs requires skilled veterinary care and often several medications to manage seizures. Some dogs respond to a single medication while others require several medications to control their condition. Zonisamide is a versatile anticonvulsant that effectively reduces seizures associated with refractory epilepsy.  Prescription Zonisamide is often used as an initial treatment for epilepsy and works alone for some dogs. It’s particularly useful for dogs that cannot tolerate other epilepsy medications, including phenobarbital and potassium bromide, which can have adverse side effects.  Zonisamide can also be used with potassium bromide and phenobarbital for epileptic dogs that need – and can tolerate – the combination of medications. Your veterinarian will provide guidance on the right medications to help control your dog’s seizures. Ask your veterinarian about required rechecks while your pet is on this medication and what tests may need to be performed prior to using Zonisamide.

 

What you should know about Zonisamide:

  • Talk to your veterinarian before using this product.
  • Follow dosing directions exactly - don’t give your pet more medication than directed and don’t skip doses.
  • Read the label carefully for information about storage, possible side effects, and drug interactions.

 

For additional information about Zonisamide click the “More Information” and “Package Insert” tabs above. 

Epilepsy Overview                     

Epilepsy is a brain disorder that can be caused by genetics or a physical change in the body, such as scar tissue build up in the brain. The large majority of epilepsy cases in dogs are genetic, and about three percent of all dogs will have the disease in their lifetime. Cocker Spaniels, Beagles, Dachshunds, Collies, Golden Retrievers, and Labrador Retrievers are just a few of the common breeds prone to epilepsy.  

 

The disease results in recurrent seizures, which can become more frequent over time. Seizures usually have a sudden onset and can happen in clusters or at regular intervals. They can include: loss of consciousness, physical collapse, body stiffness, sporadic limb movement, salivation, defecation, vocalization, disorientation, and other physical symptoms.

 

For many dogs, medication can reduce the number and severity of the seizures.  The two standard medications veterinarians prescribe to control epilepsy are phenobarbital and potassium bromide. While they’re effective for many dogs, these medications can have serious side effects including liver damage and lethargy. Some dogs benefit from a combination of the medications.

 

Zonisamide

Many epileptic dogs are now benefitting from a new generation of epilepsy medication, Zonisamide.  This prescription sulfonamide anticonvulsant and carbonic anhydrase inhibitor is proven to reduce seizures and control the disease for many canines. Zonisamide is effective for many dogs when used alone, but it can also be used in combination with potassium bromide and phenobarbital. Dogs that cannot tolerate the side effects of other epilepsy drugs often do well on Zonisamide. If your dog suffers from epilepsy, talk to your veterinarian about whether Zonisamide would be beneficial.  We offer Zonisamide capsules in three dosage levels.

 

Pet parents with epileptic dogs need to work closely with their veterinarians to manage the disease effectively throughout their dog’s lifetime. Regular monitoring and check ups are important. Consistency is also crucial when giving your dog anticonvulsant medications since missed doses can, in some cases, trigger seizures. 

You can find a package insert which provides more detailed information on Zonisamide Capsule's indications, forms of administration, and side effects, along with other clinical information, by following the link below:

Zonisamide Package Insert*

 

Zonisamide's Package Insert does not take the place of instructions from your veterinarian. Talk to your veterinarian if you do not understand the information provided in this document or if you have any questions about Zonisamide antiseizure medication for dogs.

 

*This link opens in a new window.

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

18 Questions | 18 Answers
Displaying questions 1-10Previous | Next »
  • Q:

    I have a 145 lb gsh/weimer. He has seizures about every 4 day He take 6 pho\6 keppra/ and now the vet put him on 8 100 mg of zonisamide aday. Is this just to much med. He having trouble walking now!!!
    Asked on 4/19/2015 by Bobbie from Wellington, KS, United States

    1 answer

    • A:

      When a pet is on a combination of antiseizure medications often times dose adjustments with these drugs are necessary when adding additional drug therapies to your pet’s treatment regimen. Please contact your veterinarian to discuss the adverse effects you’re observing so he or she can make the appropriate changes to your pet’s therapy.

      Thank you,
      VetRxDirect

      Answered on 4/24/2015 by VetRxDirect
  • Q:

    Do you keep Zonisamide in stock and do I have to have my vet to call it in?
    Asked on 4/14/2015 by Lari from Gaffney South Carolina

    1 answer

    • A:

      Lari,

      We do have Zonisamide in stock right now and we would need to place an order first, then we send a fax to the vet for the approval or they can call in the prescription once you have placed an order.

      Thank you,
      VetRxDirect

      Answered on 4/15/2015 by VetRxDirect
  • Q:

    What are the possible side effects of missing a dose?  My pup is currently taking the 25g dose.  I've run out of pills and will not be able to pick up the prescription until tomorrow morning.  Last dose was at 8:30am.
    Asked on 2/25/2015 by Mara from Austin, TX, United States

    1 answer

    • A:

      Mara,

      Zonisamide is used as either monotherapy or in addition to another medication for the management of seizure disorders. The usual dosing frequency of this medication is every 12 hours (ie. twice daily). Based on this dosing, your dog will miss their evening dose of this medication. As this medication is used to help control the occurrence of seizures, an increase in seizures could potentially occur. Your dog should resume taking this medication as soon as possible, as abrupt, prolong discontinuation of this medication can lead to the occurrence of “rebound” seizures. Contact your veterinarian if you have any concerns regarding the health of your dog.

      Thank you,
      VetRxDirect

      Answered on 3/6/2015 by VetRxDirect
  • Q:

    My dog tolerate zonegran 100mg tablets (twice/day) very well. it's there any different on drug effect between capsules and tablets? My dog may need to try capsule as no tablets can be ordered from website now. Thank you.
    Asked on 1/29/2015 by Zaku from Hong kong

    1 answer

    • A:

      Zonisamide is only available in the United States in an immediate release capsule form. We are unaware of any commercially available tablet form of this product. If you are receiving a compounded tablet from another compounding pharmacy we would not be able to verify that the dose of that medication is equivalent to the capsule form that is currently available. Please consult your veterinarian prior to starting or stopping any new medications for your pet.

      Answered on 2/9/2015 by VetRxDirect
  • Q:

    What are the side effects of zonisamide for a dog? Minature Schnauzer is taking 75mg 2 times a day. He weighs about 21 lbs.
    Asked on 11/11/2014 by graham from Mocksville, NC, United States

    1 answer

    • A:

      Graham,

      Adverse events that have been reported from zonisamide use in veterinary patients include sedation (usually temporary), abnormal muscle movements including coordination issues with walking or standing and inappetence. Maintain a log of seizure frequency to keep track of the drug efficacy while on zonisamide. Document all side effects and changes of behavior in your pet while on zonisamide. Follow up with your veterinarian if the side effects become bothersome to you or your pet.

      Thank you,
      VetRxDirect

      Answered on 11/17/2014 by VetRxDirect from VetRxDirect
  • Q:

    How much zonisamide should my 20 lb dog be taking.
    Asked on 11/8/2014 by Jkelleyx from NH

    1 answer

    • A:

      You will need to talk to your veterinarian about any dosing instructions. They will be the one prescribing the medication.

      Thank you,
      VetRxDirect

      Answered on 11/11/2014 by VetRxDirect from VetRxDirect
  • Q:

    What side effects does this medication have on dogs. I have a 115 pound Rottweiler who has had 6 seizures in one day. The Vet prescribed 300 mg. every 8 hours for him. But after the first dosage his legs were weak, and was lethargic?
    Asked on 7/19/2014 by clfletch5 from Fresno, CA, United States

    1 answer

    • A:

      Common adverse effects for zonisamide include sedation, uncoordinated movement, and loss of appetite. We suggest you contact your veterinarian to notify him or her of this so the best therapy can be given to your pet.

      Thank you,
      VetRxDirect

      Answered on 7/23/2014 by VetRxDirect from VetRxDirect
  • Q:

    Can you tell me where the zonisamide pills you have are manufactured?
    Asked on 7/7/2014 by Mew1960

    1 answer

    • A:

      It depends on the manufacturer that we receive from our distributor. Most of them are manufactured in India.

      Thank you,
      VetRxDirect

      Answered on 7/9/2014 by VetRxDirect from VetRxDirect
  • Q:

    You have explained that Zonisamide is a generic. The capsules pictured are a different color from the ones I get at the pharmacy, so I assume they are from a different manufacturer. How stringent are the formulas from maker to maker to assure consistency?
    Asked on 6/6/2014 by jerseyjack from Los Angeles, CA, United States

    1 answer

    • A:

      Zonisamide is a human-labelled medication prescribed for pets. Generics must provide evidence that they have the same active drug (i.e. zonisamide) and drug strength as well as the same effect by the drug when taken. Zonisamide medications from different manufacturers should have similar effect(s) on your pet and would be considered equivalents to one another.

      Thank you,
      VetRxDirect

      Answered on 6/10/2014 by VetRxDirect from VetRxDirect
  • Q:

    Is this Zonisamide the original product, or a generic? Thanks.
    Asked on 6/4/2014 by jerseyjack from Los Angeles, CA, United States

    1 answer

    • A:

      Zonisamide is the drug name or generic name for the medication. Zonegran is the original brand name of the medication, but rarely would that be filled as the generic has be available for several years. We only carry generic zonisamide.

      Thank you,
      VetRxDirect

      Answered on 6/4/2014 by VetRxDirect from VetRxDirect
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REVIEW SNAPSHOT®

by PowerReviews
GlenmarkZonisamide
 
4.5

(based on 15 reviews)

Ratings Distribution

  • 5 Stars

     

    (10)

  • 4 Stars

     

    (3)

  • 3 Stars

     

    (1)

  • 2 Stars

     

    (1)

  • 1 Stars

     

    (0)

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Most Liked Positive Review

 

So thankful for this medicine!

My 11 year old beagle, Cali, started having seizures in late September of 2013! �The. After the first one they started coming every two weeks. �Each seizure lasted...Read complete review

My 11 year old beagle, Cali, started having seizures in late September of 2013! �The. After the first one they started coming every two weeks. �Each seizure lasted about 1 minute, but anyone who has seen their dog go through one .. it's about 1 minute too long! �After her seizures started occurring she became lethargic and I was afraid this was it! �After her 3rd seizures and multiple tests, Cali's vet finally prescribed her zonisamide. �She takes 75mg twice a day! I cannot tell you how thankful I am for this medicine. It has brought me peace of mind now that she is no longer having seizures and it has brought my fun loving little girl back to life! �Verrxdirect has also been a blessing in allowing me to purchase her medicines for such a reasonable price! Thank you!!!! And to mom and dads out there who are first experiencing the horror of watching their baby go through seizures I can tell you - it does it easier! �I had many sleepless nights watching her worried with the dread of anticipation she was going to have one and after the first one and doing research I learned how to better handle them no help her through! And when the medicine was prescribed a weight was lifted off both mine and Cali's shoulders!

VS

Most Liked Negative Review

 

Out of Stock/Unavailable

I have been purchasing my dog's Zonisamide (epilepsy meds) from RxDirect for quite some time but this last time they were out of stock/unavailable. When I called to ask when they would...Read complete review

I have been purchasing my dog's Zonisamide (epilepsy meds) from RxDirect for quite some time but this last time they were out of stock/unavailable. When I called to ask when they would have some available, they were apologetic but unable to give me any specific date for their re-stock. This medicine can't be interrupted and I will have to go elsewhere to get the medicine. This was unexpected and I am disappointed at the inconvenience of having to call my Vet to call the local pharmacy, and know I will pay more for it.

Reviewed by 15 customers

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5.0

Simply the best!

By 

from Undisclosed

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

Easy and convenient! Great prices! Quick delivery. What more can you ask for?
Alison Brigham

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5.0

My dogs little pill

By 

from Dallas,TX

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

I'm so happy that I found Vetrxdirect. They make it easy for me to order online and they deliver within a few days. I highly recommend Vetrxdirect to any pet owner that needs medications or any supplies for their furry loved ones. My Cocker Spaniel has to be on seizure medications x2 a day and I have relied on Vetrxdirect to provide her with the best quality medication. Thanks Vetrxdirect!

Thanks,
Cass and Raven

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5.0

4 months and going strong!!!

By 

from New York, USA

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

Our dog of 3 years has recently been diagnosed with epilepsy. He has been on this medicine for 4 months and hasn't had a single seizure (knock on wood). This is an easy way to get his medicine delivered right to our door without any hassles! They also add a homemade treat for our pup in the box.... Which he loves! Thank you so much for going above and beyond.

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5.0

The staff were very helpful in the order process.

By 

from Bethlehem, PA, USA

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

So far so good; my dog appears to have no reaction at all to the medication and the staff were so helpful in the ordering process, made it easy. And it was delivered quickly as well.

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4.0

Medicine

By 

from Duluth, MN, USA

Verified Buyer
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Comments about Glenmark Zonisamide:

I tried to buy this medicine from a local pharmacy and it was much more expensive. My vet doesn't supply it.

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5.0

What a Value!

By 

from Lincoln, NE, USA

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

I was not surprised by the cost of my pet's new medication at my pharmacy. After an internet search, I was amazed I could save so much on the exact same medication at Vetrxdirect!

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5.0

Works great

By 

from Levittown, NY, USA

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Comments about Glenmark Zonisamide:

Since my dog has been on this medication he has not has a seizure

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4.0

Seizure medication

By 

from Undisclosed

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Comments about Glenmark Zonisamide:

I have used this medication for my schnauzer for seizures for a couple of years. He has had no side affects as some of the other medications have caused and his seizures have dropped drastically... This med is more pricier than others, but I feel well worth it...

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5.0

Good product, great price

By 

from Texas, USA

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Comments about Glenmark Zonisamide:

No fuss, no bother. Received product without any problems

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4.0

great service, changes in pill size

By 

from Chicago, IL, USA

Verified Buyer
Site Member

Comments about Glenmark Zonisamide:

I moved over to VetRx after a bad experience with another online company and because of their customer service and quick responses via email, I will never change to another company.
In regards to Zonisamide.. the pill has not caused any issues for my boston terrier, but recently the pill has changed to a much larger size which has made it difficult for my dog to swallow. I know that VetRx was recently out of stock with Zonisamide so I'm not sure if this has anything to do with the size changing. Hoping they go back to the smaller version.

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