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S-Adenosyl

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S-Adenosyl

Many people use the supplement S-Adenosyl, commonly known as SAMe, and swear by the results. Now pets can benefit form this natural supplement too. SAMe is a detoxifier and antioxidant with many properties that help dogs and cats.

  •  Supports healthy liver function
  •  Relieves pain and swelling due to osteoarthritis
  •  Improves cognitive function
  •  Snap Tabs variation provides four equal parts for a wide range of weights.

SAMe is best known for improving liver function and metabolic activity in dogs and cats. But this powerful supplement containing milk thistle does much more. SAMe helps treat cognitive disorders, depression, and hepatitis. It’s also effective in treating osteoarthritis by reducing inflammation and helping to regenerate joint tissue.

 

What you should know about S-Adenosyl:

  •  Talk to your veterinarian before using this product.
  •  Follow dosing directions exactly - don’t give your pet more medication than directed and don’t skip doses.
  •  Read the label carefully for information about storage, possible side effects, and drug interactions.

 

For additional information about S-Adenosyl, click the “More Information” and “Package Insert” tabs above. 

You can find a Client Information Sheet which provides a summary of information about S-Adenosyl by following the link below:

SAMe Client Information Sheet*

 

If you have questions or concerns about S-Adenosylmethionine, or conditions related to its use, contact your pet's veterinarian or pharmacist.

 

*This link opens in a new window.

You can find a package label which provides more detailed information on S-Adenosyl's indications, forms of administration, and side effects, along with other clinical information, by following the link below:

S-Adenosyl 100 Package Label*

S-Adenosyl 225 Package Label*

S-Adenosyl 425 Package Label

 

S-Adenosyl's package insert does not take the place of instructions from your veterinarian. Talk to your pet’s veterinarian or pharmacist if you do not understand the information provided in this document or if you have any questions about S-Adenosyl SAMe made with milk thistle for dogs.

 

*This link opens in a new window.

 

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

12 Questions | 12 Answers
Displaying questions 1-10Previous | Next »
  • Q:

    does S-Adenosyl-100 come in liquid form
    Asked on 1/5/2015 by suitsee from Long Beach, CA, United States

    1 answer

    • A:

      S-Adenosyl is not available in a liquid form. We will keep an eye out for SAMe liquid and add it to our site if it becomes available.

      Answered on 1/7/2015 by VetRxDirect from VetRxDirect
  • Q:

    My dog is being treated for dementia.  Sam-e with milk thistle 1 tab daily.  Dog is small can't hide pill in food anymore.  Does it come in liquid form.
    Asked on 11/24/2014 by Sandy25 from Port St. Lucie, FL, United States

    1 answer

    • A:

      Yes, this does come in a liquid form, we do not carry it however. We just have the pill form.

      Thank you,
      VetRxDirect

      Answered on 11/25/2014 by VetRxDirect from VetRxDirect
  • Q:

    Is milk thistle the same as Sam E? I ntoiced it was more affordable? My dog has high liver enzymes.
    Asked on 9/18/2014 by IzzyD from Tucson, AZ, United States

    1 answer

    • A:

      Although both are used as supplements in liver dysfunction, S-adenosylmethionine (SAMe) is not the same as milk thistle. SAMe is a molecule naturally made in the body, which helps in brain, liver, and other tissue function. Supplemental SAMe is thought to increase liver cell function in animals with decreased liver function. Milk thistle (silymarin) is thought to improve liver function by acting as an anti-oxidant and anti-inflammatory agent, protecting the liver cells from toxins as well as increasing the amount of protein liver cells made. Milk thistle is commonly listed in products as Silybin A and B, which are extracts of silymarin. SAMe and milk thistle can be used together or alone. It would be important to discuss with your pet’s veterinarian in order to select the safest and most appropriate supplement for your pet.

      Thank you,
      VetRxDirect

      Answered on 9/25/2014 by VetRxDirect from VetRxDirect
  • Q:

    i've do a research and i've found an article said not to give milk with SAMe for cat . Why?
    Asked on 5/17/2014 by blicious from Thailand

    1 answer

    • A:

      There is not an apparent drug-food interaction with SAMe and milk. However, SAMe should be given on an empty stomach, at least one hour before feeding your cat, because food and other products, such as milk, may decrease the effectiveness of SAMe. This is because they may decrease the absorption of SAMe in the GI tract. You should be able to feed your cat milk after an hour of giving SAMe.

      Thank you,
      VetRxDirect

      Answered on 5/22/2014 by VetRxDirect from VetRxDirect
  • Q:

    Is there a comparable liquid milk thistle extract for my dog. Many challenges to administering s-a caps and I'm an expert at med disguises. Good results with the product when successfully ingested.
    Asked on 3/6/2014 by Boj1 from Fairfax county va

    1 answer

    • A:

      We are not aware of any liquid options for the milk thistle or SAMe supplements. You may want to check in with your dog's veterinarian on additional administration options or other supplements that may be easier to administer.

      Thank you,
      VetRxDirect

      Answered on 3/13/2014 by VetRxDirect from VetRxDirect
  • Q:

    are these the non chewable pills?
    Asked on 1/24/2014 by davec from Phoenix, AZ, United States

    1 answer

    • A:

      We carry both forms of the S-Adenosyl supplement, the non-chewable tablets and the chewable. If you are looking for chewable tablets, they are available in one strength, the 225, and are listed as snap tabs, which break apart to allow for dosing at strengths other than 225. The non-chewable come in three strengths, 100, 225, and 425.

      Thank you,
      VetRxDirect

      Answered on 1/24/2014 by VetRxDirect from VetRxDirect
  • Q:

    Re: the S-Adenosyl 225 mg............. are those Snap Tabs that are scored inm quarters and can be chewed?  How long would delivery be to 60156.  Ship Charge?  Thanks.
    Asked on 1/16/2014 by Cherri from Lake in the Hills, IL, United States

    1 answer

    • A:

      Cherri,

      We carry both the S-Adenosyl tablets (in three strengths, including 225mg) and the snap tabs. The snap tabs are only available in the 225mg strength (but are scored in fourths for adjusting dosing and are considered chewable). Most over-the-counter orders ship within 1 to 2 business days and standard shipping is a guarantee of 5 to 8 business days for delivery. We have expedited shipping options available, full information on shipping can be found here: http://www.vetrxdirect.com/faq#shipping. Standard shipping is free (for qualifying items, including the S-Adenosyl) on orders over $39.00.

      Thank you,
      VetRxDirect

      Answered on 1/17/2014 by VetRxDirect from VetRxDirect
  • Q:

    What is the difference between the subject items? My vet had ordered the S-Adenosyl-100 and liver enzymes have gone down from 1200 to 900 but would the 425 accomplish more?
    Asked on 11/20/2013 by Donna

    1 answer

    • A:

      Donna,

      The appropriate dosing for S-Adenosyl is determined by your pet's weight.

      S-Adenosyl 100 is dosed as follows:

      Cats: 1 tablet daily

      Dogs under 20 pounds: 1 tablet daily

      Dogs 21 to 40 pounds: 2 tablets daily

      Dogs 41 to 60 pounds: 3 tablets daily

      Dogs over 60 pounds: 4 tablets daily

       

      The S-Adenosyl 425 is dosed as follows:

      Dogs 40 to 80 pounds: 1 tablet daily

      Dogs over 80 pounds: 2 tablets daily

       

      The number following the name indicates the strength of the supplement.  The S-Adenosyl 100 has 100mg of s-adenosyl-L-methionine per tablet and the S-Adenosyl 425 has 425mg of s-adenosyl-L-methionine.

      Thank you,

      VetRxDirect

      Answered on 11/21/2013 by VetRxDirect
  • Q:

    Is the human supplement s-adenosyl safe for dogs
    Asked on 10/14/2013 by Sheila

    1 answer

    • A:

      Sheila,

      S-Adenosyl methionine (SAMe) is a natural-occurring chemical found in the body and is classified as a nutritional supplement and not a pharmaceutical drug. This active chemical, SAMe, will be the same for both animal and human products but additional supplements and inactive ingredients may be present in these products. Due to the variety of SAMe-containing products that exist, we recommend you discuss the product with your veterinarian to verify dosing and safety.

      Thank you,

      VetRxDirect

      Answered on 10/15/2013 by VetRxDirect
  • Q:

    Is there generic med for S-Adenosyl-225 if so what kind and were I can get it?
    Asked on 9/5/2013 by Shanna

    1 answer

    • A:

      Shanna,

      S-Adenosyl's main ingredient is commonly referred to as SAMe. SAMe is found in many OTC products. You can find many by using our site search above.

      Thank you,

      VetRxDirect

      Answered on 9/6/2013 by VetRxDirect
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REVIEW SNAPSHOT®

by PowerReviews
SogevalS-Adenosyl
 
4.7

(based on 18 reviews)

Ratings Distribution

  • 5 Stars

     

    (16)

  • 4 Stars

     

    (1)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (1)

100%

of respondents would recommend this to a friend.

Pros

No Pros

Cons

No Cons

Best Uses

No Best Uses
    • How would you rate the value of this product?:
    •  
    • How would you rate the quality of this product?:
    •  
    • Was this a gift?:
    • No (4)

Most Liked Positive Review

 

w/ diet, a dramatic drop in elevated liver enzymes

I don't know whether I can credit SAMe-425 alone for the improvement (I also began supplementing my dog's diet with dandelion smoothies and kefir, increased her dose of vitamin E and fish...Read complete review

I don't know whether I can credit SAMe-425 alone for the improvement (I also began supplementing my dog's diet with dandelion smoothies and kefir, increased her dose of vitamin E and fish oil, and broke up her home-cooked diet to 5 small meals per day), but after 3 months of the combined regimen, my 8-year-old blue heeler's liver enzymes went from off-the-charts high to high normal. Now, 5 months later, the values are completely within normal - about a 300% drop from when she was first diagnosed with advanced hepatobiliary disease. Her doctor said that she'd never seen anything like this. Again, I made several dietary changes at the same time she started taking SAMe-425, so I can't say this medication alone is responsible for the dramatic improvement. Still, much credit has to be given to SAMe-425, since previously a healthy, organic, home-cooked diet had not offset her serious liver problems. I definitely recommend it.

VS

Most Liked Negative Review

 

Best Quality

I have been purchasing s-adenosyl-100 for my dog and found that I can purchase 60days
worth of these pills for the same price my vet charges me for 30 days.

I have been purchasing s-adenosyl-100 for my dog and found that I can purchase 60days
worth of these pills for the same price my vet charges me for 30 days.

Reviewed by 18 customers

Displaying reviews 1-10

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5.0

This works

By 

from Essexville, MI

Verified Buyer

Comments about Sogeval S-Adenosyl:

I give this to my shih tzu daily with her Selegiline

  • Was this a gift?:
  • No
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  •  
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  •  
 
5.0

My vet recommended this product for my aging lab

By 

from Kyburz CA

Verified Buyer

Pros

  • Super fast delivery - thanks

Cons

    Best Uses

      Comments about Sogeval S-Adenosyl:

      Dog had seizures and is on Phenobarbital

      • Was this a gift?:
      • No
      • How would you rate the quality of this product?:
      •  
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      •  

      (1 of 1 customers found this review helpful)

       
      5.0

      I will be buying this again

      By 

      from Essexville, MI

      Verified Buyer

      Comments about Sogeval S-Adenosyl:

      It's been wonderful and my Shih Tzu has shown major improvement taking this with Selegiline, for 10 1/2 years old...it's like I have my puppy back again.

      • Was this a gift?:
      • No
      • How would you rate the quality of this product?:
      •  
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      •  

      (1 of 1 customers found this review helpful)

       
      5.0

      Great Product

      By 

      from Missouri

      Comments about Sogeval S-Adenosyl:

      My Scottie had serious liver issues and we were in danger of losing him, or at best much more expensive medicine and treatment. With this pill, recommended by my vet, we have brought his bad test results into an acceptable range and he is enjoying good health.

      • Was this a gift?:
      • No
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      •  
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      •  

      (1 of 1 customers found this review helpful)

       
      5.0

      Responsible and Reputable

      By 

      from Maryland

      Verified Buyer
      Site Member

      Comments about Sogeval S-Adenosyl:

      The SAMe product came shipped free of charge, the product price was excellent and, well, my dog would probably die w/o this product... so I am thrilled to have such great support with my dog's health through such a reputable and responsible company!

      • How would you rate the quality of this product?:
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      (1 of 1 customers found this review helpful)

       
      4.0

      Great

      By 

      from Palmdale, CA, USA

      Site Member

      Comments about Sogeval S-Adenosyl:

      Always buy this product from this company. They deliver fast

      • How would you rate the quality of this product?:
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      (1 of 1 customers found this review helpful)

       
      5.0

      Used for elevated liver labs

      By 

      from Minneapolis, MN, USA

      Verified Buyer
      Site Member

      Comments about Sogeval S-Adenosyl:

      My dog has been on this for elevated liver enzymes which was related to food allergies. We have been giving this to her for some time, once daily. This plus diet modification has resulted in normalization of liver values. Of interesting note is our previous dog was on it too, vet advised, for cognitive changes associated with aging, that dog lived to 17 years old and it improved his mentation as manifested by not aimlessly wandering in house.

      (1 of 1 customers found this review helpful)

       
      5.0

      Can't beat the price!

      By 

      from Pottsville, PA, USA

      Verified Buyer
      Site Member

      Comments about Sogeval S-Adenosyl:

      Great product that is working wonders for our Riley & his Liver issues! Cost is less than half the price , at his Vets! Same Brand too.

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      5.0

      S-Adenosyl(SAMe)

      By 

      from Secaucus, NJ, USA

      Verified Buyer
      Site Member

      Comments about Sogeval S-Adenosyl:

      My dachshund has a history of having high liver enzymes (app. over 1400 in early 2014).now in Dec. 2014 her enzymes dropped to over 600. Also, she was diagnosed with Cushing's Disease which keeps her level of enzymes high - S-Adenosyl(SAMe) helps keep the level down. Really Helpful!

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      5.0

      Works Great!

      By 

      from Billings Mt

      Verified Buyer
      Site Member

      Comments about Sogeval S-Adenosyl:

      My minature schnauzer has been on this for years. Her liver does not process animal protein. She has enjoyed good health being a vegan and taking s-andesol.

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