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Prednisolone Transdermal Gel (Compounded) Rx

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Prednisolone Transdermal Gel (Compounded) for Dogs and Cats.


Why has my veterinarian prescribed Prednisolone Transdermal Gel?

Prednisolone/prednisone is a corticosteroid. This type of medication is prescribed to relieve inflamed areas, decrease swelling, redness, itching, allergic reactions and for supportive care during stressful periods. Your veterinarian may also prescribe this medicine for other conditions.


How do I give Prednisolone Transdermal Gel?

  • Give Prednisolone/Prednisone to your pet as directed by your veterinarian.
  • Give this medication after meals or with food.
  • Try to give this medication at the same time each day.
  • Generally, if this medicine is prescribed once a day, give it in the morning to dogs and in the evening to cats. This schedule closely mimics their natural hormone cycle.
  • If Prednisolone/Prednisone is prescribed as a liquid, measure the dose carefully.
  • DO NOT stop giving this medication suddenly, especially if your pet has been on it for a long time. Consult with your veterinarian before you stop giving this medication.
  • DO NOT give your pet more medicine than directed.
  • DO NOT give your pet medicine more often than prescribed.
  • Try not to miss giving any doses.


If I miss a dose, what do I do?

If you miss a dose, give it to your pet as soon as possible. If it is almost time for the next dose, skip the missed dose, then continue with the regular dosing schedule. Do not give your pet two doses at once.


How do I store Prednisolone Transdermal Gel?  

Keep this medicine out of reach of children.


Store this medicine at room temperature in a dry, cool place. Keep this medicine away from heat and direct sunlight.


Do not store this medicine in damp places, in the bathroom, or near the kitchen sink. This medication can break down when exposed to moisture or heat.


What are the potential side effects of Prednisolone Transdermal Gel?

The following side effects have been reported: excessive thirst, excessive appetite, excessive urination, dull or dry haircoat, weight gain, panting, vomiting, diarrhea, stomach upset, muscle wasting, depression, lethargy, behavioral changes such as irritability. If symptoms persist or appear troublesome, contact your veterinarian.


Prednisolone/Prednisone suppresses the immune system, which means your pet may have an increased risk of infection. Contact your veterinarian if your pet develops a fever or shows signs of frequent or painful urination.


If your pet is diabetic, prednisolone/prednisone may cause changes to your pet's insulin requirements.


Other side effects may occur. If you notice anything unusual, contact your veterinarian.


What about possible drug interactions?

Be sure to tell your veterinarian about any other medications or supplements you are giving your pet.


It’s not uncommon for your veterinarian to prescribe two different medications, which may cause a drug interaction to occur. If this happens, your veterinarian may change the dose and/or monitor your pet more closely.


The following drugs can potentially interact with Prednisolone/Prednisone: amphotericin B, potassium depleting diuretics, digitalis glycosides, salicylates, insulin, phenytoin, phenobarbital, rifampin, cyclosporin, cyclophosphamide, mitotane, non-steroidal anti-inflammatory drugs, and anticholinesterase agents.


Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.


Beyond Use Date:

  • Transdermal: It is recommended that this product be used within 90 days.


Protective finger cots or examination gloves should be worn when applying this medication.


Prednisolone and Temaril-P (trimeprazine with prednisolone) Tablets are also available at VetRxDirect.