Why has my veterinarian prescribed Palladia?
Toceranib Phosphate is a kinase inhibitor prescribed to treat recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs. This medication may also be useful for treating a variety of tumors in dogs, including sarcomas, carcinomas, melanomas, and myeloma. The trade name for Toceranib Phosphate is Palladia® Tyrosine.
What should I talk to my veterinarian about before giving my pet this medication?
Talk to your veterinarian about any required rechecks while on this medication and what tests may need to be performed prior to and during treatment with this drug. Also ask your veterinarian about the risks and benefits of using this drug. Be sure to tell your veterinarian about all medicines and supplements that you give your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
This medication should not be given to dogs that are:
Because Toceranib Phosphate can cause vascular dysfunction leading to edema and thromboembolism (blood clots in the blood vessels including pulmonary emboli), wait at least 3 days after stopping medication before performing surgery.
How do I give Palladia?
If I miss a dose, what do I do?
If you miss a dose, give it to your pet as soon as possible. If it is almost time for the next dose, skip the missed dose, then continue with the regular dosing schedule. Do not give your pet two doses at once.
How do I store Palladia?
Keep this medicine out of reach of children and pets.
Store this medicine at room temperature in a dry, cool place. Keep this medicine away from heat and direct sunlight.
What are the potential side effects of Palladia?
The most common adverse effects are of Toceranib Phosphate are: diarrhea, decreased/loss of appetite, lameness, weight loss and blood in the stool.
There are other potential adverse effects including muscle cramping, nasal depigmentation, change in coat or skin color, and seizures. These adverse effects can be serious and require treatment, a pause in administering the medication, or a dose reduction so careful monitoring of your pet’s condition is essential.
If your pet has severe diarrhea or blood in the stool it may require immediate treatment so contact your veterinarian right away.
What about possible drug interactions?
Toceranib Phosphate may interact with: NSAIDS, piroxicam, ketoconazole, fluconazole, itraconazole, grapefruit juice, clarithromycin, and verapamil.
What about overdosing?
Contact your veterinarian immediately if your pet receives more than the prescribed amount.
Palladia's Drug Insert for veterinary reference opens in a new window.