Diethylstilbestrol, commonly abbreviated DES, is a medication used to treat estrogen responsive urinary incontinence (wetting themselves or inability to hold urine) in spayed female dogs. It is also used to treat benign prostatic hypertrophy, BPH, which is an enlarged prostate in male dogs.
Diethylstilbestrol capsules are compounded by VetRxDirect’s expert compounding staff. They are available in many dosage forms to tailor to your pet’s needs. The capsules need to be stored away from humidity, light, and heat. It is important to order your refills a few days ahead of time because the product needs to be made for your pet. DES capsules have an expiration date of 20 weeks after they are made, so pay close attention to expiration dates on your label. Quantities and charges ordered exceeding the beyond use date will be adjusted to hopefully prevent your pet’s medication from expiring before they are finished.
Description of Medicine:
This medication is typically used to treat estrogen responsive incontinence in spayed female dogs and benign prostatic hypertrophy in male dogs. It works by acting on estrogen hormone receptors, although the compound itself is not a steroid.
Cautions and Warnings:
This medication should be used cautiously in older animals as they will be more susceptible to adverse effects. This medication is normally contraindicated in pregnancy, unless specifically prescribed by a veterinarian during pregnancy.
How to Use this Medication:
This medication is usually prescribed as 0.1-1.0 mg daily for five days. After this, the dose is usually reduced to 1-3 times per week. Dosing regimens may vary with weight and disease state.
Possible Side Effects:
Side effects are typically limited to those that are caused by excess estrogen. This includes bone marrow depression, feminization of male dogs, increased risk of pyometra (an infection of the uterus), and increased risk of estrogen-sensitive tumors. Side effects tend to be more prevalent with higher dosages and in older animals. Contact veterinarian if signs and symptoms of lethargy, diarrhea, vomiting, abnormal discharge from vulva, excessive water consumption and urination, or abnormal bleeding occur.
Beyond Use Date:
1. Plumb DC. Diethylstilbestrol. Plumb’s veterinary drug handbook. 5th ed. 2005.
2. Papich MG. Diethylstilbestrol. Saunders Handbook of Veterinary Drugs. 2nd 2007.