Amitriptyline Compounded Gel for Cats - PCAB ACRD - VetRxDirect
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Amitriptyline Transdermal Gel (Compounded) Rx

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Compounded Amitriptyline Transdermal Gel

Amitriptyline is a prescription anti-depressant drug called a tricyclic, that affects certain chemicals in the brain that are unbalanced. It it used to control behavior problems in dogs and cats such as anxiety, separation anxiety, excessive grooming, and urine spraying in cats. It is also used in the treatment of chronic nerve pain and severe itching. If your pet has been diagnosed with a behavior disorder your veterinarian may prescribe an antidepressant medication like Amitriptyline. The Amitriptyline transdermal gel is applied topically to a hairless portion of the skin, typically the inner side of the ear lobe, where it absorbs through the skin into the bloodstream. This method is suggested for pets who are difficult to administer oral medication. It is compounded in 2mg, 2.5mg, 3.5mg, 5mg, 7.5mg, 10mg, and 12.5mg strengths. COnsult with your pet’s veterinarian before administering this medication.  

  • Read and follow the prescription label carefully for storage information, possible side effects, and drug interactions.
  • Give the exact amount prescribed and only as often as directed.
  • Do not skip doses or stop giving the medication without consulting your veterinarian.
  • For additional information, click the “Package Insert” and “More Information” tabs

Beyond Use Date:

Due to the shelf life of this medication it is recommended that this product be used within 60 days of the compounding date.


Protective finger cots or examination gloves should be worn when applying transdermal gels.

You can find a Client Information Sheet which provides a summary of information about Amitriptyline by following the link below:

Amitriptyline Client Information Sheet*


If you have questions or concerns about Amitriptyline, or conditions related to its use, contact your pet's veterinarian or pharmacist.


*This link opens in a new window.