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Zentonil Plus

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Zentonil® Plus SAMe (S-adenosylmethionine) Nutritional Supplement Tablets for Dogs and Cats

 

What is SAMe?

SAMe (S-adenosylmethionine) is the bioactive form of methionine, an essential amino acid or “building block” of protein. These amino acids are plentiful in foods, but especially concentrated in meat and sunflower seeds. Supplementing a diet with methionine alone, however, does not necessarily raise the level of bioactive methionine, or SAMe, dramatically.

 

SAMe is one of the most commonly used supplements in human and animal medicine. SAMe contains both sulphur and methyl groups and is part of more than 40 key chemical reactions in the body. Methylation reactions in the body are required to form adequate levels of brain chemicals called neurotransmitters. SAMe helps synthesize all neurotransmitters related to catecholamines, including epinephrine and dopamine. Deficiencies of epinephrine and dopamine can lead to depression and Parkinson's disease.  In human clinical trials SAMe has shown significant promise in treating these disorders and other cerebral disorders including autism, peripheral neuropathy, spinal cord degeneration, and Alzheimer's disease.

 

The sulphur groups of SAMe are also metabolically important. Glutathione, a critical detoxifier and antioxidant, is made from SAMe. SAMe itself also functions as an antioxidant. These antioxidant and detoxifying properties mean that SAMe is able to reduce liver damage such as cirrhosis.

 

SAMe has several other effects in the body. It plays an important role in:

  • estrogen breakdown
  • the synthesis of carnitine, which is important for adequate heart function
  • the synthesis of choline, which is important for cognition and brain function
  • the synthesis of melatonin, which allows sleep
  • the synthesis of nucleic acids so that cells can divide
  • the degradation of histamine, which reduces inflammation
  • the synthesis of collagen

 

SAMe is also an analgesic (pain reliever). Because of its pain reducing capabilities, ability to promote collagen and cartilage synthesis, and its anti-inflammatory properties, SAMe is commonly used in osteoarthritis. In clinical trials, the efficacy of SAMe in relieving arthritic pain has approached that of many NSAIDs.

 

Why is my veterinarian recommending SAMe for my pet?

SAMe is widely prescribed for the same purposes in animals as it is in people. SAMe is used to treat canine cognitive disorders, suspected depression, osteoarthritis, and hepatitis. It can also be used to treat various neurological disorders, including degenerative myelopathy. SAMe is appropriate for all species, since it is naturally present in all mammals. It is probably most commonly used in dogs because of their susceptibility to liver and musculoskeletal disorders.

 

How safe is SAMe?

SAMe is important in the treatment of osteoarthritis, because it reduces inflammation and pain and also helps regenerate joint tissue.

 

Because of its extremely low toxicity, SAMe is probably one of the first treatments that should be considered for treating arthritic dogs and cats. The side effects of SAMe are rare, and limited to mild nausea and gastrointestinal irritation. Use SAMe with caution in hyperexcitable animals, because it may increase excitability.

 

Where do I get SAMe and do I need a prescription?

You do not need a prescription for SAMe. Purchase supplements with caution and know the manufacturer, as supplements are not highly regulated and some supplements may not contain the labeled amount of ingredients. Consult your veterinarian about his or her preferred brands or supplement sources

You can find a package label which provides more detailed information on Zentonil Plus indications, forms of administration, and side effects, along with other clinical information, by following the link below:

 

Zentonil Plus 100 mg Tablets for Small Dogs and Cats Package Label*

Zentonil Plus 200 mg Tablets Small and Medium Dogs Package Label*

Zentonil Plus 400 mg Tablets Medium and Large Dogs Package Label*

  

Zentonil Plus package insert does not take the place of instructions from your veterinarian. Talk to your pet’s veterinarian or pharmacist if you do not understand the information provided in this document or if you have any questions about Zentonil Plus palatable nutritional supplement.

 

*This link opens in a new window.

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

1 Question | 1 Answer
Displaying question 1
  • Q:

    Our 13 yr old poodle has liver disease. We have been treating her with zentonil since since 7/2012. Her ALT is 813 u/l and the ALKP is 1741 u/l.  Could we switch her to S-adenosyl without repercussions?  All other blood tests are in the normal range. 
    Asked on 1/30/2014 by SueG from Jefferson City, MO, United States

    1 answer

    • A:

      Sue,

      Zentonil Plus is a nutritional supplement, S-adenosylmethionine (SAM-e), used for liver support. Zentonil Plus is available in 100mg, 200mg, and 400mg of SAM-e. The manufacturer’s suggested dosing is based on the weight of your pet. Switching to an alternative with the same active ingredient, SAM-e, and same dose strength should have similar benefits. We recommend consulting with your veterinarian on all supplements used to support your pet’s health.

      Thank you,
      VetRxDirect

      Answered on 2/5/2014 by VetRxDirect from VetRxDirect
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VetoquinolZentonil Plus
 
5.0

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5.0

Great product

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from Fall River, MA

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Comments about Vetoquinol Zentonil Plus:

I've bought this item the past few months and will reordering once I finish this survey.

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5.0

Good Product

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from Arkansas, USA

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Comments about Vetoquinol Zentonil Plus:

Have been using product for months on my dog due to high liver levels. It does help in keeping them lower. Love being able to mail order.

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5.0

Fairly priced

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from New York, NY, USA

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Comments about Vetoquinol Zentonil Plus:

After the vet put my cat on Zentonil, I struggled to find a reliable place to buy it. It is also very reasonably priced, especially at this larger dose (which is easy to cut in half).

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5.0

Great results

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from Pittsburgh, PA, USA

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Comments about Vetoquinol Zentonil Plus:

My 11 year old dog has severe arthritis in her front legs and shoulders and also has an under active thyroid. Had her on Rimadyl for pain for a while but it impacted her liver. A few weeks on Zentonil helped her liver test results, she appears more alert and happy. Only give her Rimadyl now when we take her out to appointments.

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