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Trilostane (Compounded) Rx

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Compounded Trilostane for the Treatment of Cushing’s Disease in Dogs

Beyond Use Date:

   Capsules: It is recommended that this product be used within 6 months.

   Suspension: It is recommended that this product be used within 3 months.


To provide the freshest product possible, VetRxDirect prepares our compounded medications as directed after we receive prescription authorization from your veterinarian.  Occasionally, this may add an additional day or two to our shipping terms.  We appreciate your understanding of this policy. 
Order online today or please call or e-mail VetRxDirect's compounding pharmacist at 866-761-6578 or if your veterinarian has prescribed any variation from the listed dose strengths or quantities of this compounded medication.

Compounded Trilostane

Prescription Trilostane is proven effective at easing the symptoms of Cushing’s Disease, also known as hyperadrenocorticism. Dogs with this disease produce too much of the hormone cortisol. Trilostane regulates cortisol production in the adrenal gland. The right dosage amount is critical to effective treatment, which is why we compound Trilostane in dozens of strengths and two different formulations.


  •  Controls cortisol production
  •  Helps manage the adrenal-dependent and pituitary-dependent forms of Cushing’s Disease
  •  Reduces symptoms
  •  Compounded in dozens of strengths to match your dog’s needs
  •  Two formulations – convenient capsules or beef flavored liquid


Many dogs with Cushing’s Disease require a daily dose of Trilostane to regulate cortisol levels in their blood. Our compounding pharmacy makes giving your pet that critical daily dose more effective and easier. While Trilostane is commercially available in only four capsule strengths, we compound it into dozens of strengths to closely match your dog’s specific needs. We also offer the medication in capsules or beef flavored liquid for easy dosing. Administering Trilostane daily will help regulate the cortisol levels in your dog’s bloodstream and will reduce symptoms of the disease over time.


What you should know about Compounded Trilostane:

  •  Talk to your veterinarian before using this product.
  •  Follow dosing directions exactly - don’t give your pet more medication than directed and don’t skip doses.
  •  Read the label carefully for information about storage, possible side effects, and drug interactions.


For additional information about Compounded Trilostane, click the “More Information” and “Package Insert” tabs above. 



You can find a Client Information Sheet which provides a summary of information about Compounded Trilostane for Dogs by following the link below:


Trilostane Client Information Sheet*


If you have questions or concerns about Trilostane, or conditions related to its use, contact your pet's veterinarian or pharmacist.


*This link opens in a new window.

Trilostane (Compounded) Capsules or Suspension Rx

Medication Fact Sheet


Description of Medicine:

Trilostane is a medication used to treat hypercortisolemia (Cushing's Disease or hyperadrenocorticism), which is an increase in the amount of cortisol in the blood.  Trilostane is primarily used in dogs and occasionally in cats. It can also be used to treat pituitary pars intermedia dysfunction in horses (equine Cushing's Disease) and to treat Alopecia-X in dogs.  It works by inhibiting cortisol synthesis through inhibiting a key enzyme (3-beta-hydroxysteriod dehydrogenate) that allows cortisol to be released from the adrenal cortex.


Some common signs and symptoms of chronic excessive cortisol are as follows:  frequent urination, excessive drinking, excessive appetite, lethargy (decreased activity), excessive panting, pot belly, thick skin, hair loss, recurrent skin disease and muscle wasting.  All of these signs DO NOT need to be present in your animal to be treated with trilostane.  Improvement of symptoms such as excessive thirst, excessive hunger, and frequent urination, can be seen within a few weeks after starting therapy.  However, therapy may need to persist despite resolution of these signs and symptoms.


Cautions and Warnings:

Do not use trilostane in dogs that have demonstrated a hypersensitivity to trilostane; have renal/hepatic disease; or are pregnant.  Teratogenic effects (birth defects) and early pregnancy loss in lab animals has been shown with trilostane administration.  Studies in breast-feeding dogs and those used for breeding have not been performed.  Trilostane should not be used in combination with medications that can cause a decrease in aldosterone (blood pressure medications such as ACE inhibitors, spironolactone) because effects may be additive, making it difficult for the animal to maintain normal electrolyte levels and blood volume. 


Keep this medication out of the reach of children.  Trilostane is not for human use.  Owners should wash hands after administering this medication to the animal.  Do not empty capsule contents and do not attempt to divide the capsules.  Do not attempt to handle the capsules if you are pregnant or trying to conceive because trilostane is associated with teratogenic effects and early pregnancy loss in animals.  Studies have not been performed in women who are breast-feeding.  Seek medical attention if there is accidental ingestion/overdose and have the labeled container with you.


How to Use this Medication:

This medication is taken by mouth once to twice daily with food because food increases absorption of the medication.  After 10-14 days of therapy, the dog will need to be re-examined and a 4-6 hour post-dosing ACTH stimulation test will be performed to determine cortisol levels in the blood.  A dosage adjustment may be made following this test.  Every time a dosage adjustment occurs, this test needs to be administered 10-14 days after the new dose is started.  If no dosage adjustment is needed, the dog needs to be re-examined at 30 days, 90 days, and every 3 months thereafter.  Such careful monitoring is needed due to the fluctuation in cortisol levels, electrolytes, renal/hepatic function and blood volume.  It is important to follow all instructions from your veterinarian and keep all follow-up appointments to ensure the maximum benefit and avoidance of adverse events from the medication.


Possible Side Effects:

In some dogs, lethargy, anorexia, diarrhea, weakness, or vomiting may be observed.  Electrolyte concentrations, cortisol levels, and renal/hepatic function will need to be monitored.  If you think your animal has a medical problem or intolerance develops to trilostane, stop the medication and contact the veterinarian immediately.


Beyond Use Date:

   Capsules: It is recommended that this product be used within 6 months.

   Suspension: It is recommended that this product be used within 3 months.


Storage Requirement:

   Capsules, suspension: Store at room temperature in a tightly sealed container, protected from light.

   Keep out of reach from children to avoid accidental ingestion.



1.     Papich MG. Trilostane. Saunders Handbook of Veterinary Drugs. 2nd ed. 2007.

2.     Vetoryl (trilostane) [Package Insert]. Overland Park, KS: Dechra Veterinary Products; 2008.