Simplicef for Dogs: Cefpodoxime for dogs -
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Simplicef (cefpodoxime proxetil) Rx

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Simplicef (cefpodoxime proxetil) Antibiotic Tablets for Pets

What is Simplicef?

 Simplicef is the brand name product for an antibiotic called cefpodoxime proxetil. It can be used for bacterial infections, but especially skin infections. It is FDA approved for dogs only, but may be useful in cats under direct veterinarian supervision.

What dogs should not take Simplicef?

 If your dog has had an allergic reaction to any cephalosporin antibiotics, they should not take Simplicef. It should also be used with caution in dogs with a history of seizures.

What to expect while your dog’s on Simplicef?

Simplicef is generally well tolerated but it can cause diarrhea and vomiting. Your dog’s infection should clear up with Simplicef, but it is important to finish the entire course of antibiotics that your pet's veterinarian directed. If your pet’s infection has not cleared up after finishing a course of Simplicef, you should consult the veterinarian. It can be given with or without food.


Resistance is a major concern when giving antibiotics.  Resistance occurs when bacteria survive and mutate and are then able to survive even after antibiotics are given.  To help avoid resistance, it is important to give antibiotics as they are prescribed for as long as they are prescribed even if your pet is looking and feeling better.


You can find a Client Information Sheet which provides a summary of information about Simplicef Tablets for Pets by following the link below:

Simplicef Client Information Sheet*


If you have questions or concerns about Simplicef Tablets, or conditions related to its use, contact your pet's veterinarian or pharmacist.


*This link opens in a new window.

You can find a package insert which provides more detailed information on Simplicef Tablets' indications, forms of administration, and side effects, along with other clinical information, by following the link below:

Simplicef Package Insert*


Simplicef's Package Insert does not take the place of instructions from your pet's veterinarian. Talk to your pet's veterinarian if you do not understand the information provided in this document or if you have any questions about Simplicef Tablets for Dogs.


*This link opens in a new window.