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Simplicef (cefpodoxime proxetil) Rx

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Simplicef (cefpodoxime proxetil) Antibiotic Tablets for Pets

What is Simplicef?

 Simplicef is the brand name product for an antibiotic called cefpodoxime proxetil. It can be used for bacterial infections, but especially skin infections. It is FDA approved for dogs only, but may be useful in cats under direct veterinarian supervision.

What dogs should not take Simplicef?

 If your dog has had an allergic reaction to any cephalosporin antibiotics, they should not take Simplicef. It should also be used with caution in dogs with a history of seizures.


What to expect while your dog’s on Simplicef?

Simplicef is generally well tolerated but it can cause diarrhea and vomiting. Your dog’s infection should clear up with Simplicef, but it is important to finish the entire course of antibiotics that your pet's veterinarian directed. If your pet’s infection has not cleared up after finishing a course of Simplicef, you should consult the veterinarian. It can be given with or without food.

 

Resistance is a major concern when giving antibiotics.  Resistance occurs when bacteria survive and mutate and are then able to survive even after antibiotics are given.  To help avoid resistance, it is important to give antibiotics as they are prescribed for as long as they are prescribed even if your pet is looking and feeling better.

 

You can find a Client Information Sheet which provides a summary of information about Simplicef Tablets for Pets by following the link below:

Simplicef Client Information Sheet*

 

If you have questions or concerns about Simplicef Tablets, or conditions related to its use, contact your pet's veterinarian or pharmacist.

 

*This link opens in a new window.

You can find a package insert which provides more detailed information on Simplicef Tablets' indications, forms of administration, and side effects, along with other clinical information, by following the link below:

Simplicef Package Insert*

 

Simplicef's Package Insert does not take the place of instructions from your pet's veterinarian. Talk to your pet's veterinarian if you do not understand the information provided in this document or if you have any questions about Simplicef Tablets for Dogs.

 

*This link opens in a new window.

Do you have questions about this product?

Get answers from real customers and in-house experts with AnswerBox.

3 Questions | 3 Answers
Displaying questions 1-3
  • Q:

    My puppy has been on for 3 days pukes in morning1 time do dogs stay on it even when pukes sometimes 
    Asked on 10/22/2014 by chocolate from Minneapolis, MN, United States

    1 answer

    • A:

      The primary side-effects of Simplicef (cefpodoxime proxetil) may include diarrhea and vomiting. If these side-effects occur often, they can affect your pet’s ability to take or absorb the medication. Especially if the vomiting and diarrhea occur around administration of a dose. Frequent vomiting and diarrhea can also cause dehydration in your pet. Taking this medication with food is usually recommended and may help, but if this side-effect continues, you should report it to your pet’s veterinarian. Your pet’s veterinarian will be able to determine if the therapy is still effective, if a longer duration is needed, if the dose may be too high, and how to best minimize any side-effects in the future.

      Thank you,
      VetRxDirect

      Answered on 11/3/2014 by VetRxDirect from VetRxDirect
  • Q:

    Can cefopodxime and bendrayl be given together?
    Asked on 6/19/2014 by Songie from Bahamas

    1 answer

    • A:

      Songie,

      There are no drug interactions between cefpodoxime and Benadryl (brand named diphenhydramine) and can be safely given together. Keep in mind that cefpodoxime is an antibiotic and may cause allergic reactions in whomever may be susceptible. If this is the case and reason for the Benadryl administration, we recommend having frequent follow up by your veterinarian.

      Thank you,
      VetRxDirect

      Answered on 6/26/2014 by VetRxDirect from VetRxDirect
  • Q:

    Simplicef 100 mg seems to be the only medication that helps our 10 yr old cocker with her skin problems but they start to get bad again after 1-2 weeks of being off simplicef. How safe is this to give all the time and if safe to give daily? Thanks. Buni
    Asked on 3/26/2014 by Buni from Paducah KY

    1 answer

    • A:

      Buni,

      This drug, along with the other antibiotics in its class, are generally considered safe in dogs. It would be hard to predict any specific side effects your dog may experience from taking it daily long-term. Keeping up with all of the lab and veterinary appointments will help monitor for any long-term problems. Keeping a close eye on your dog and coordinating with the veterinarian are great ways to prevent a problem from happening with this medication, should one occur.

      Thank you,
      VetRxDirect

      Answered on 4/1/2014 by VetRxDirect from VetRxDirect
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Zoetis Inc.Simplicef (cefpodoxime proxetil)
 
5.0

(based on 3 reviews)

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5.0

release to ship antibiotics may have you waiting

By 

from Chicago, IL, USA

Verified Buyer
Site Member

Comments about Zoetis Inc. Simplicef (cefpodoxime proxetil):

Simplicef worked great! Product came as described. The price was good. Some shipping issues though.

Sending VetRxDirect your prescription to release and ship the antibiotic may have you waiting longer then you wanted to. Communication between my vet and VetRxDirect had my deathly sick dog "Tank" waiting a couple extra days for the Simplicef.

In the end, after the prescription issue was taken care of and VetRxDirect sent my purchase with upgraded shipping. My dog is healthy again, thank you so much VetRxDirect :)

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5.0

Works great on my dog with hot spots!

By 

from Sacramento, CA, USA

Verified Buyer
Site Member

Comments about Zoetis Inc. Simplicef (cefpodoxime proxetil):

My 9 year old fur baby suffers hot spots every spring. The vets has prescribed him in the past just about everything, temaril-P, cortisone shots, multiple medicated dips, Malaseb shampoo, derma-vet ointment, simplicef, & some others I can't think of right this moment. But Simplicef along with derma-vet ointment(animax), and malaseb shampoo together seems to help calm the itching and the hot spots goes away. My dog is currently on a 10 day simplicef dose, once a day. It is 6th day, I have given him two baths with Malaseb shampoo within the 6 days and animax ointment directly on the hot spots. I noticed it clearing up within the first day, and as of today he is no longer itching or licking, no scabs, or fresh wounds, and his skin is back to light pink. I have used the malaseb shampoo by itself and that didn't clear up the wounds. I've also used up a 15ml tube derma-vet ointment but the hot spots were so overwhelming, only parts of his body cleared up. I truly think the oral medication Simplicef help tremendously along with the baths and ointment. As his whole body is now clear of hot spots. It may again just be temporary until the medication is gone. I have used vetrxdirect in the past and with comparison of how much the vet charges, I save twice if not three times the $$ ordering from vetrxdirect. I will continue to use them or future orders.

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5.0

Saved me a lot of money!

By 

from Virginia

Verified Buyer
Site Member

Comments about Zoetis Inc. Simplicef (cefpodoxime proxetil):

I am so happy that Vetrxdirect had the generic Simplicef for my dog who needed to on this antibiotic for over a month now....

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