Primidone: Seizures and Epilepsy in Dogs - VetRxDirect
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Primidone (Generic) Tablets: Anti-Seizure Medication for Use in Dogs Only

Primidone is a medication used to treat seizures in dogs. It is sometimes recommended for pets who are not responding well to phenobarbital. Primidone is converted to phenobarbital and PEMA, also known as phenylethylmalonamide. Some veterinarians believe that PEMA may help to treat seizures better than phenobarbital alone.

Potential adverse effects:

  • liver toxicity

  • anxiety when initiating treatment

  • agitation when initiating treatment

  • increased thirst

  • increased urination

  • increased appetite and weight gain


Signs of overdosage include sedation to coma, anorexia, vomiting, and rapid eye movements. Contact your pet's veterinarian immediately if you suspect primidone overdosage.


Primidone may interact with other medications you are giving your pet. Inform your pet's veterinarian about all medications given to your pet including non-prescription products and supplements.


It is important to give your pet this medication exactly as prescribed and to not discontinue the drug without consulting with your veterinarian. It is very important to ensure adequate treatment of seizures.

If you miss giving your pet the dose, give it to him as soon as you remember. If it is close to the next dose, skip the missed dose and continue on your normal schedule. If you are unsure about when to give a missed dose, contact your pet's veterinarian.

You can find a Client Information Sheet which provides a summary of information about Primidone Tablets by following the link below:

Primidone Client Information Sheet*


If you have questions or concerns about Primidone, or conditions related to its use, contact your pet's veterinarian or pharmacist.


*This link opens in a new window.

You can find a package insert which provides more detailed information on Primidone Tablets' indications, forms of administration, and side effects, along with other clinical information, by following the link below:

Primidone Package Insert*


Primidone's Package Insert does not take the place of instructions from your pet'sveterinarian. Talk to your pet's veterinarian if you do not understand the information provided in this document or if you have any questions about Primidone anticonvulsant tablets for dogs.


*This link opens in a new window.