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Metronidazole Transdermal Gel (Compounded) Rx

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Metronidazole (Generic) Transdermal Gel (Compounded) for Pets


Beyond Use Date:

Transdermal: It is recommended that this product be used within 30 days.

Protective finger cots or examination gloves should be worn when applying this medication.


Why has my veterinarian prescribed Metronidazole Transdermal Gel?

Metronidazole is a synthetic antibacterial and antiprotazoal agent used to treat trichomoniasis, giardiasis, balantidiasis, amoebiasis, and trypanosomiasis.


How do I give Metronidazole Transdermal Gel?



Administer Metronidazole as directed by your veterinarian.


Give this medication for as long as your veterinarian prescribes, even if it seems your pet is feeling better. This will help to ensure the infection is all cleared up.


If using liquid Metronidazole, shake the bottle well before carefully measuring the dose.


DO NOT give your pet more medicine than directed.


DO NOT give your pet medicine more often than prescribed.


Try not to miss any doses.


Because Metronidazole tablets are very bitter, do not crush them.


If I miss a dose, what do I do?

If you miss a dose, give it to your pet as soon as possible. If it is almost time for the next dose, skip the missed dose, then continue with the regular dosing schedule. Do not give your pet two doses at once.


How do I store Metronidazole Transdermal Gel?  

Keep this medicine out of reach of children.


Store capsules and tablets at room temperature in a dry, cool place. Keep this medication away from heat and direct sunlight.


Do not store this medicine in damp places, in the bathroom, or near the kitchen sink. This medication can break down when exposed to moisture or heat.


What are the potential side effects of Metronidazole Transdermal Gel?


Metronidazole can cause: weakness, sleepiness, loss of appetite, nausea, vomiting, diarrhea, and neurological disorders (e.g. lack of muscular coordination, involuntary rapid movement of the eyeball, seizures, head tilt, slow heart rate, rigidity and stiffness).


If your pet develops any neurological symptoms, call your veterinarian right away.


There are other side effects so if you notice anything unusual, call your veterinarian.


What about possible drug interactions?

Be sure to tell your veterinarian about any other medications you are giving your pet.


The following drugs have the potential to interact with Metronidazole: warfarin, phenobarbital, phenytoin, cimetidine, and alcohol.


It’s not uncommon for your veterinarian to prescribe two different medications, which may cause a drug interaction to occur. If this happens, your veterinarian may change the dose and/or monitor your pet more closely.


Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.




Metronidazole (Vet)

Medication Fact Sheet


Description of Medicine:

This medication is used to treat various infections.  Metronidazole is an antibacterial, antiparasitic, and antiprotozoal agent.  It works by disrupting the DNA in the infecting organism.


Cautions and Warnings:

This medication should not be used in animals hypersensitive to metronidazole (Flagyl) or tinidazole (Tindamax).  Metronidazole should be used cautiously in pregnancy.  Please contact your veterinarian if pregnancy is a possibility.  Metronidazole should be used with caution and may require a dosage adjustment in animals with liver dysfunction. 


How to Use this Medication:

The dosing and duration of this medication is individualized and may vary for each animal.  Follow the instructions from your veterinarian as well as the following recommendations:

·    Capsules:  Should be swallowed whole if possible.  Capsules may be opened to sprinkle content over food.  Please note that if capsule is sprinkled over food, all food should be ingested to ensure proper dosage.

·    Suspension: Shake well prior to each dose and use appropriate syringe to ensure proper dosage.  Dosage should be administered directly into the animal’s mouth if possible.  If needed, dosage may be squirted onto food.  Please note that if dosage is placed on food, all food should be ingested to ensure proper dosage.

·    Transdermal:  Supplied in multi-dose syringes; verify dose prior to administration.  Use a finger cot or glove to administer medication.


Possible Side Effects:

Side effects tend to be dose-related.  Metronidazole’s most severe side effect is dose-related CNS toxicity.  Metronidazole may cause lethargy, CNS depression, ataxia (disordered movements), nausea, vomiting, diarrhea, weakness, neutropenia (decreased white blood cells), liver toxicity, hematuria (blood in the urine), and anorexia.


Beyond Use Date:

·    Capsules: It is recommended that this product be used within 180 days.

·    Suspension: It is recommended that this product be used within 90 days.

·    Transdermal: It is recommended that this product be used within 30 days.


Storage Requirement:

·    Store metronidazole at room temperature, protected from light.

·    Keep out of reach from children to avoid accidental ingestion.



1.     Plumb DC. Metronidazole. Plumb’s Veterinary Drug Handbook. 5th ed. 2005.

2.     Papich MG. Metronidazole. Saunders Handbook of Veterinary Drugs. 2nd 2007.