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Metronidazole Transdermal Gel (Compounded) Rx

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Metronidazole (Generic) Transdermal Gel (Compounded) for Pets


Beyond Use Date:


  • Transdermal: It is recommended that this product be used within 30 days.


Protective finger cots or examination gloves should be worn when applying transdermal gels.

Metronidazole's Client Information Sheet for pet parent reference opens in a new window.


Resistance is a major concern when giving antibiotics. Resistance occurs when bacteria survive and mutate and are then able to survive even after antibiotics are given. To help avoid any resistance, it is important to give antibiotics as they are prescribed for as long as they are prescribed even if your pet is looking and feeling better.

Metronidazole (Veterinary) Medication Fact Sheet 

Description of Medicine:

This medication is used to treat various infections.  Metronidazole is an antibacterial, antiparasitic, and antiprotozoal agent.  It works by disrupting the DNA in the infecting organism.

Cautions and Warnings:

This medication should not be used in animals hypersensitive to metronidazole (Flagyl) or tinidazole (Tindamax).  Metronidazole should be used cautiously in pregnancy.  Please contact your pet's veterinarian if pregnancy is a possibility.  Metronidazole should be used with caution and may require a dosage adjustment in animals with liver dysfunction. 

How to Use this Medication:

The dosing and duration of this medication is individualized and may vary for each animal.  Follow the instructions from your pet's veterinarian as well as the following recommendations:

  • Capsules:  Should be swallowed whole if possible.  Capsules may be opened to sprinkle content over food.  Please note that if capsule is sprinkled over food, all food should be ingested to ensure proper dosage.
  • Suspension: Shake well prior to each dose and use appropriate syringe to ensure proper dosage.  Dosage should be administered directly into the animal’s mouth if possible.  If needed, dosage may be squirted onto food.  Please note that if dosage is placed on food, all food should be ingested to ensure proper dosage.
  • Transdermal:  Supplied in multi-dose syringes; verify dose prior to administration.  Use a finger cot or glove to administer medication.

Possible Side Effects:

Side effects tend to be dose-related.  Metronidazole’s most severe side effect is dose-related CNS toxicity.  Metronidazole may cause lethargy, CNS depression, ataxia (disordered movements), nausea, vomiting, diarrhea, weakness, neutropenia (decreased white blood cells), liver toxicity, hematuria (blood in the urine), and anorexia.

Beyond Use Date:

  • Capsules: It is recommended that this product be used within 180 days.
  • Suspension: It is recommended that this product be used within 90 days.
  • Transdermal: It is recommended that this product be used within 30 days.

Storage Requirement:

  • Store metronidazole at room temperature, protected from light.
  • Keep out of reach from children to avoid accidental ingestion.



  1. Plumb DC. Metronidazole. Plumb’s Veterinary Drug Handbook. 5th ed. 2005.
  2. Papich MG. Metronidazole. Saunders Handbook of Veterinary Drugs. 2nd 2007.



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1 Question | 1 Answer
Displaying question 1
  • Q:

    What if the cat ingests some of the metronidazole transdermal gel from her ear from grooming herself? Is it safe?
    Asked on 6/11/2014 by Corinna from Arlington, VA, United States

    1 answer

    • A:


      If topical metronidazole gel is applied correctly and rubbed in thoroughly, the potential exposure and risk from an amount that would be ingested after grooming, would be extremely small. The gel should be rubbed in until no gel is seen on the inner ear surface. If dried gel is noticed on the surface of the inner ear, use a wet washcloth to remove the buildup.

      Thank you,

      Answered on 6/26/2014 by VetRxDirect from VetRxDirect
Displaying question 1

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