Client Information Sheet

for

Glucosamine + Chondroitin sulfate (Rx and OTC)

General Description: Glucosamine and chondroitin has been prescribed to give your pet the building blocks necessary to repair damaged joint cartilage. As well, the anti-inflammatory properties of the ingredients will gradually build up to help support joint health in your pet. This product may be used in combination with others to achieve good results for arthritic pets. This product has also been used to treat cancer pain and may be of benefit in the treatment of lower urinary tract disease in cats. Glucosamine and Chondroitin sulfate is available in tablets, capsules, powders and oral liquids.

What is this drug?

• Cartilage components harvested mainly from shellfish, but also from shark skeleton and cattle

• A nutraceutical (a nutrient with medicinal properties) with slow acting effects (weeks to months)

• Basic starting level for joint care

• Given by mouth

Reasons for prescribing:

• To improve joint function and help with pain relief in arthritic dogs and cats

• May be used in the treatment of lower urinary tract disease in cats

• May be used to treat cancer pain

• May be used in combination with NSAIDs or other drugs

• Not helpful in joint disease involving the vertebrae and intervertebral discs

What dogs/cats should not take this medication?

• Safety in pregnant and nursing animals is unknown

• Use with caution in pets with asthma (human patients report increased asthma symptoms)

• If your pet has had an earlier allergic reaction to Glucosamine and/or Chondroitin sulfate

Directions:

Read and follow the label carefully.

These products do not produce rapid results, but need one to two months to build up within the body.

Products vary greatly. Dosage experimentation may be necessary with the help of your veterinarian. Typically the pet starts therapy at a high dose and once effects have been noticed, the dose is reduced to a maintenance level.

It is usually given once a day and is usually used for the life of the pet.

Glucosamine and Chondroitin sulfate may be given with or without food.

Arthritic pets also benefit from weight control, proper exercise and physical therapy.

Nutraceuticals are not regulated by the FDA. As such, they have not been required to go through the same rigorous testing for efficacy that drugs undergo. Many products on the market are high quality and are made by reputable companies. Consult with your veterinarian to choose a sound product for your pet.

What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

• When will your pet need to be rechecked

• What tests may need to be performed prior to and during treatment with this drug

• What are the risks and benefits of using this drug

Tell your veterinarian about:

• If your pet has experienced side-effects on other drugs/products

• If your pet has experienced digestive upset now or ever

• If your pet has experienced any other medical problems or allergies now or ever

• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet’s medicines can be given together.

• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Potential side effects:

• These products are usually well tolerated

• Clinically insignificant decrease in platelet function (blood clotting)

• Stomach upset is possible, but are usually mild and include flatulence and soft bowel movements

• High doses could enhance effects of anticoagulants

• If you notice anything unusual, contact your veterinarian

Can this drug be given with other drugs?

• Yes, but interactions may occur with anticoagulants, aspirin, doxorubicin, etoposide, phenylbutazone or other drugs that influence platelet function.

• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Overdosing?

If your pet receives more than the prescribed amount, contact your veterinarian immediately.

What else should I know?

Notify your veterinarian if your animal’s condition does not improve or worsens despite this treatment.

As with all prescribed medicines, Glucosamine and Chondroitin sulfate should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about Glucosamine and Chondroitin sulfate. If you have any questions or concerns about Glucosamine and Chondroitin sulfate or the condition it was prescribed for, contact your veterinarian.

Glucosamine + Chondroitin sulfate (Rx and OTC)

Trade Names:

Adroitin-M™ Chewables

Adroitin-M™ Soft Chews

Adroitin™ Treats (with Fatty Acids)

BERRIER™ J&H Canine

Canine Myristol®

Cosequin® DS Capsules

Cosequin® DS Chewable Tablets

Cosequin® For Cats

Cosequin® RS Capsules

Cosequin® Soft Chews For Dogs

Dasuquin® For Cats

Dasuquin® For Large Dogs

Dasuquin® For Small to Medium Dogs

Dasuquin® With MSM For Large Dogs

Dasuquin® With MSM For Small to Medium Dogs

DuraFlex™ Soft Chew Treats

Fastrack® Senior Dog Supplement

GLC® 1000 Canine Powder Concentrate

GLC® 1000 Capsules

GLC® 1000 Small Dog Capsules

Joint MAX® Regular Strength Capsules For Smaller Dogs and Cats

Joint MAX® Regular Strength Chewable Tablets For Smaller Dogs and Cats

Joint MAX® Sprinkle Capsules for Cats

K9 Essential Nutrition™

Probios® Dog Treats (Hip & Joint)

Rejuvenate™

Resources™ Canine Re-Flex™ 1

Restor-A-Flex™ Tablets

Seraquin® Chewable Tablets for Cats and Dogs (800 mg)

Seraquin® Chewable Tablets for Dogs (2 g)

Sergeant's® Vetscription® Joint-Eze™ Plus

Vetri-Disc

General Description:

Glucosamine and chondroitin has been prescribed to give your pet the building blocks necessary to repair damaged joint cartilage. As well, the anti-inflammatory properties of the ingredients will gradually build up to help support joint health in your pet. This product may be used in combination with others to achieve good results for arthritic pets. This product has also been used to treat cancer pain and may be of benefit in the treatment of lower urinary tract disease in cats. Glucosamine and Chondroitin sulfate is available in tablets, capsules, powders and oral liquids.

What is this product?

• Cartilage components harvested mainly from shellfish, but also from shark skeleton and cattle
• A nutraceutical (a nutrient with medicinal properties) with slow acting effects (weeks to months)
• Basic starting level for joint care
• Given by mouth

Reasons for prescribing:

• To improve joint function and help with pain relief in arthritic dogs and cats
• May be used in the treatment of lower urinary tract disease in cats
• May be used to treat cancer pain
• May be used in combination with NSAIDs or other drugs
• Not helpful in joint disease involving the vertebrae and intervertebral discs

What dogs/cats should not take this product?

• Safety in pregnant and nursing animals is unknown
• Use with caution in pets with asthma (human patients report increased asthma symptoms)
• If your pet has had an earlier allergic reaction to Glucosamine and/or Chondroitin sulfate

Directions:

Read and follow the label carefully.

These products do not produce rapid results, but need one to two months to build up within the body.

Products vary greatly. Dosage experimentation may be necessary with the help of your veterinarian. Typically the pet starts therapy at a high dose and once effects have been noticed, the dose is reduced to a maintenance level.

It is usually given once a day and is usually used for the life of the pet.

Glucosamine and Chondroitin sulfate may be given with or without food.

Arthritic pets also benefit from weight control, proper exercise and physical therapy.

Nutraceuticals are not regulated by the FDA. As such, they have not been required to go through the same rigorous testing for efficacy that drugs undergo. Many products on the market are high quality and are made by reputable companies. Consult with your veterinarian to choose a sound product for your pet.

What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving this product?

Talk to your veterinarian about:

• When will your pet need to be rechecked
• What tests may need to be performed prior to and during treatment with this drug
• What are the risks and benefits of using this drug

Tell your veterinarian about:

• If your pet has experienced side-effects on other drugs/products
• If your pet has experienced digestive upset now or ever
• If your pet has experienced any other medical problems or allergies now or ever
• All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
• If your pet is pregnant or nursing or if you plan to breed your pet

Storage and Warnings:

Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.

Keep this and all medication out of reach of children and pets.

Potential side effects:

• These products are usually well tolerated
• Clinically insignificant decrease in platelet function (blood clotting)
• Stomach upset is possible, but are usually mild and include flatulence and soft bowel movements
• High doses could enhance effects of anticoagulants
• If you notice anything unusual, contact your veterinarian

Can this product be given with other products/drugs?

• Yes, but interactions may occur with anticoagulants, aspirin, doxorubicin, etoposide, phenylbutazone or other drugs that influence platelet function.
• If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.

Overdosing?

If your pet receives more than the prescribed amount, contact your veterinarian immediately.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, Glucosamine and Chondroitin sulfate should only be given to the pet for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about Glucosamine and Chondroitin sulfate. If you have any questions or concerns about Glucosamine and Chondroitin sulfate or the condition it was prescribed for, contact your veterinarian.

COSEQUIN® RS CAPSULES

Nutramax Labs.

ORIGINAL RESEARCHED BRAND

#1 Veterinarian Recommended Brand™▼

Sprinkle Capsules for Small Animals

GUARANTEED ANALYSIS-EACH CAPSULE CONTAINS:

Ingredients: Glucosamine hydrochloride (derived from shellfish), sodium chondroitin sulfate (derived from bovine cartilage), gelatin, manganese ascorbate, water, mixed glycosaminoglycans, magnesium stearate, and sodium lauryl sulfate.

*Not recognized as an essential nutrient by the AAFCO Dog and Cat Food Nutrient Profiles.

†Cosequin^® contains FCHG49^® Glucosamine and TRH122^® Sodium Chondroitin Sulfate, Nutramax Laboratories^® proprietary veterinary researched specifications.

▲Reported on a hydrous basis.

♦From manganese ascorbate.

Store in a cool, dry area out of direct sunlight. Keep lid tightly secured to ensure freshness. Keep out of reach of children.

This bottle contains (1) non-toxic desiccant to help preserve freshness and ensure the shelf life of the product.

ADMINISTRATION AS A SUPPLEMENT FOR DOGS AND CATS

Dogs and Cats:

Under 10 lbs. - 1/2 - 1 capsule daily

10-24 lbs. - 2 capsules daily (1 in the morning & 1 in the evening)

Cosequin^®DS (double strength) is recommended for larger dogs (over 25 lbs.). Cosequin is available in flavored sprinkle capsules for cats.

The recommended initial administration period is four to six weeks. Your pet may respond in a shorter period of time. At this time you can decrease the number of Cosequin capsules to a level that maintains your pet’s comfort. The capsules can be pulled apart and the contents sprinkled on the pet’s food. Wet or moist food is preferred to ensure that the pet gets the entire amount.

▼ Source: Surveys conducted in November 2009 of small animal veterinarians who recommended oral joint health supplements.

U.S. Patent No. 5,587,363

Visit Cosequin.com

NUTRAMAX LABORATORIES, INC., Edgewood, MD 21040

nutramaxlabs.com

1-800-925-5187